IGF-1 LR3

Name: IGF-1 LR3
Brand: Mindful Research
Price: 28.0 USD
Availability: InStock

$28.00

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Size 0.1 MG (100 MCG)

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For research use only. Not for human or animal consumption. Purchase implies acknowledgement of these restrictions. No medical or dietary applications. All products are research chemicals and must be handled by qualified professionals.

Test Reports

0.1 MG - IGL0312J - 04/03/2025

Properties

Name:	IGF-1 LR3
Vial Contents:	Lyophilized Powder
CAS Number:	946870-92-4
Also Known As:	Long Arginine 3-IGF-1
Molecular Weight:	9117.5 g/mol
Molecular Formula:	C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

IGF-1 LR3 Peptide Synopsis

IGF-1 LR3 (insulin-like growth factor-1 long arginine 3) is aN amalgam of insulin-like growth factor-1. Due to its high efficacy and resistance to IGF-1 binding proteins, IGF-1 LR3 remains active for an impressive 120 times longer than traditional IGF-1. This remarkable peptide promotes cell division, enhances fat metabolism, and accelerates muscle repair and growth by inhibiting myostatin. Additionally, research indicates that IGF-1 LR3 may even have potential benefits for lactating mothers with young infants.

Source: Pubchem

IGF-1 LR3 Peptide Research

About

IGF-1 LR3, a modified version of insulin-like growth factor-1, is a peptide that plays a significant role in cell division, proliferation, and communication. Unlike traditional IGF-1, IGF1-LR3 has a longer half-life of 120 times due to structural changes, including the addition of 13 amino acids to the N-terminal end and the conversion of glutamic acid to arginine. These modifications also result in IGF1-LR3 not binding as strongly to IGF binding proteins.

Glucocorticoids

Glucocorticoids, produced mainly by the adrenal glands, are vital medications used to manage pain and decrease inflammation in conditions like autoimmune diseases, neurological injuries, and cancer. However, these medications often come with unwanted side effects, including muscle loss, weight gain, and weakened bones. There is further research in implementing IGF-1 LR3 to reduce the side effects of glucocorticoids and thus allow for more effective therapy.

Longevity

In addition to promoting tissue repair and maintenance throughout the body, IGF1-LR3 also acts as a protective molecule against cell damage and the effects of aging. Studies in cows and pigs have shown that administering IGF1-LR3 may effectively offset the effects of cellular aging. Ongoing research in mice is examining the potential of IGF1-LR3 to prevent the progression of conditions such as dementia, muscle atrophy, and kidney disease. This research further supports the potential of IGF-1 administration to extend lifespan and reduce disability.

Cells

IGF-1 LR3, like IGF-1, is a powerful trigger for cell growth and duplication. Its main impact is on connective tissues such as muscles and bones, but it also encourages cell division in other vital organs like the liver, kidney, nerves, skin, lungs, and blood. Considered a "maturation hormone," IGF-1 promotes not just cell proliferation, but also their specialization. Essentially, IGF-1 aids cells in reaching their full potential and fulfilling their unique purposes.

IGF-1 LR3 has a unique ability to remain in the bloodstream for extended periods, making it a highly potent molecule. When compared to IGF-1, a dose of IGF-1 LR3 provides three times more cell activation. It's important to note that IGF-1 LR3 and its derivatives do not promote cell enlargement, but rather stimulate cell division and proliferation. In muscle tissue, for example, IGF-1 LR3 does not cause cells to increase in size but rather increases the total number of muscle cells.

METABOLISM & GLUCOSE

IGF1-LR3 works to enhance fat metabolism by binding to both the IGF-1R and insulin receptors. This process promotes greater glucose absorption by muscle, nerve, and liver cells, leading to a decrease in blood sugar levels. As a result, both adipose tissue and the liver are activated to improve overall metabolic function and process glycogen & triglycerides.

Due to its ability to lower blood sugar, it's not surprising that IGF1-LR3 also decreases insulin levels and the need for additional insulin in diabetes. This typically results in a 10% reduction in insulin needs to maintain stable blood sugar levels. This information may aid in finding ways to decrease insulin doses for those with decreased sensitivity, and possibly even prevent type 2 diabetes altogether.

Growth Differentiation Factor 8 (Myostatin)

Myostatin is a key muscle protein that has a major role in limiting the growth and development of muscle cells. While this function is crucial for preventing uncontrolled growth and promoting healing after an injury, there are instances where blocking myostatin's actions could be advantageous. Suppressing myostatin's function may be beneficial in conditions such as Duchenne muscle dystrophy or for individuals experiencing muscle depletion due to extended periods of immobility. In these situations, inhibiting this innate enzyme could potentially delay muscle breakdown, preserve strength, and improve overall health.

In mouse models of DMD, IGF-1 LR3 and other derivatives have been shown to counteract the harmful effects of myostatin and protect muscle cells from apoptosis. Its long half-life makes IGF1-LR3 particularly effective at blocking myostatin, as it activates the muscle growth protein MyoD, which is typically triggered by exercise or tissue damage.