Isometric diagram of a teal peptide ribbon fitting into one highlighted pocket of a seven-transmembrane receptor with an indigo glow at the binding site, representing a melanocortin-receptor research peptide
Mindful Research

PT-141: A Melanocortin-Receptor Research Peptide (In Vitro)

Updated By: Mindful Research Team1 min read

Key takeaways

  • PT-141 is a synthetic peptide studied in vitro solely for binding to melanocortin receptors.
  • Melanocortin receptors are a family of G-protein-coupled receptors.
  • It is described only by structure and molecular target, with no physiological effect.
  • Characterized with receptor-binding and cell-based signaling assays (e.g. cyclic AMP).
  • Supplied as a research material for in vitro research use only.

PT-141 is a synthetic peptide studied in vitro solely for its binding to melanocortin receptors, a family of G-protein-coupled receptors. This profile describes the compound strictly at the level of receptor biochemistry.

What is PT-141?

PT-141 is a synthetic melanocortin-receptor-targeting peptide used as a research material. It is described here only by structure and molecular target, with no reference to any physiological effect.

Its receptor target

PT-141 binds members of the melanocortin receptor family. In cell models expressing these receptors, researchers characterize its binding and the resulting change in receptor signaling state.

How it is studied in vitro

Characterization uses receptor-binding assays and cell-based signaling readouts (such as cyclic AMP) in cells engineered to express the target receptor, compared against proper controls.

Why it is of research interest

As a defined melanocortin-receptor ligand, PT-141 is a tool for probing that receptor family in a reproducible laboratory system.

Related research guides

Research-use note

PT-141 is supplied as a research material for in vitro research use only. It is not for human or animal use.

Related research: PT-141.

Frequently asked questions

What is PT-141?

A synthetic melanocortin-receptor-targeting peptide, studied in vitro as a research material and described only by its receptor target.

What receptor does it bind?

Members of the melanocortin receptor family, a group of G-protein-coupled receptors.

How is it studied in vitro?

With receptor-binding assays and cell-based signaling readouts such as cyclic AMP in cells expressing the target receptor.

Why is it of research interest?

As a defined melanocortin-receptor ligand, it is a tool for probing that receptor family.

Research use only?

Yes, in vitro laboratory research use only.

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