Abstract amber HPLC chromatogram with a single dominant peak on a dark background, representing COA purity verification when sourcing PT-141 research material.
Mindful Research

Sourcing PT-141 as a Research Material: COA & Purity

By: Mindful Research Team2 min read

Key takeaways

  • When sourcing PT-141, rely on a batch-specific COA rather than the label.
  • Check HPLC purity with a chromatogram and MS identity near 1025.18 g/mol.
  • Confirm CAS 189691-06-3 and that the lot number matches your vial.
  • Red flags: generic COAs, purity with no chromatogram, or any implied human or animal use.
  • For in vitro research use only.

If you are looking for PT-141 for sale as a research material, judge the supplier by its batch-specific certificate of analysis: HPLC purity, mass-spectrometry identity near 1025.18 g/mol, and CAS 189691-06-3 matched to the lot. This guide covers what to check when sourcing PT-141 for in vitro work.

What should a PT-141 certificate of analysis show?

COA item What to look for
Lot number Matches the vial you receive, with a test date
HPLC purity Chromatogram with one dominant peak and a stated percent purity
Mass spectrometry Observed mass consistent with C50H68N14O10 (1025.18 g/mol average)
Identifiers Bremelanotide, CAS 189691-06-3
Form Lyophilized powder, with net peptide content if reported

How do you read HPLC purity and the MS result?

HPLC purity is the share of the main peak's area among all detected peaks; a clean dominant peak supports a high-purity claim. Mass spectrometry then confirms that the main peak is the right molecule. Both are needed, because a pure peak of the wrong peptide is still the wrong material. How the expected ions are calculated is shown in PT-141 name variants and mass-spec verification.

What are the red flags when buying a research peptide?

  • A generic COA with no lot number or date.
  • A purity figure with no chromatogram.
  • No mass-spectrometry data, or a CAS number that does not match.
  • Marketing that implies human or animal use, which a genuine research-use-only supplier does not make.

Where can you source PT-141 as a research material?

Happy Peptides supplies PT-141 (bremelanotide, CAS 189691-06-3, about 99% by HPLC) as a lyophilized research material, with batch documentation, for in vitro use only. Before ordering, you can review the compound's chemistry in the PT-141 structure and melanocortin-receptor profile guide.

Find a COA: every PT-141 batch report is listed in our certificate of analysis library, searchable by batch number.

Related research guides

Research-use note

All materials discussed are supplied for in vitro laboratory research use only, and are not for human or animal use.

Frequently asked questions

What should I check when buying PT-141 as a research material?

Check for a batch-specific certificate of analysis with HPLC purity, mass-spectrometry identity near 1025.18 g/mol, and CAS 189691-06-3 matched to your lot. View PT-141

What does HPLC purity tell me?

It reports the share of the main peak among all detected peaks; a single dominant peak supports a high-purity claim.

Why is mass spectrometry also needed?

It confirms the main peak is the right molecule, since a pure peak of the wrong peptide is still the wrong material. Verify identity by CAS and mass spec

What are red flags on a COA?

A missing lot number or date, a purity figure with no chromatogram, no mass-spec data, or a CAS number that does not match.

Is it for human or animal use?

No. It is supplied for in vitro laboratory research use only.

Continue reading

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